William W Hope Selected Research

deoxycholate drug combination amphotericin B

10/2018	A Phase 3 Study of Micafungin Versus Amphotericin B Deoxycholate in Infants With Invasive Candidiasis.
5/2015	Pharmacodynamics of amphotericin B deoxycholate, amphotericin B lipid complex, and liposomal amphotericin B against Aspergillus fumigatus.
1/2014	Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days.
11/2010	The initial 96 hours of invasive pulmonary aspergillosis: histopathology, comparative kinetics of galactomannan and (1->3) β-d-glucan and consequences of delayed antifungal therapy.
8/2010	Pharmacokinetics and pharmacodynamics of amphotericin B deoxycholate, liposomal amphotericin B, and amphotericin B lipid complex in an in vitro model of invasive pulmonary aspergillosis.
8/2005	Surface response modeling to examine the combination of amphotericin B deoxycholate and 5-fluorocytosine for treatment of invasive candidiasis.

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William W Hope Research Topics

Disease

16	Aspergillosis 01/2019 - 04/2007
15	Invasive Fungal Infections 12/2017 - 04/2007
14	Hernia (Hernias) 09/2022 - 01/2007
14	Invasive Pulmonary Aspergillosis 01/2017 - 07/2006
13	Infections 09/2021 - 10/2007
12	Body Weight (Weight, Body) 12/2017 - 01/2007
11	Candidiasis (Moniliasis) 01/2018 - 11/2006
10	Meningoencephalitis 10/2019 - 01/2008
10	Mycoses (Diseases, Fungus) 06/2017 - 06/2008
8	Ventral Hernia 09/2020 - 01/2008
8	Wounds and Injuries (Trauma) 09/2019 - 05/2009
7	Invasive Candidiasis 10/2018 - 08/2005
6	Critical Illness (Critically Ill) 03/2021 - 05/2010
6	Neoplasms (Cancer) 01/2018 - 01/2007
4	Lung Injury 01/2017 - 06/2009
3	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 01/2018
3	Obesity 01/2022 - 01/2018
3	Renal Insufficiency (Renal Failure) 01/2022 - 01/2018
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022 - 01/2018
3	Inflammation (Inflammations) 09/2021 - 04/2009
3	Schistosomiasis (Bilharziasis) 09/2021 - 01/2016
3	Surgical Wound Infection 07/2021 - 08/2017
3	Inguinal Hernia (Direct Inguinal Hernia) 01/2021 - 06/2015
3	Pain (Aches) 05/2020 - 01/2017
3	Mucormycosis 01/2017 - 01/2016
2	Hypoalbuminemia 01/2022 - 01/2018
2	Incisional Hernia 11/2020 - 01/2017
2	Pneumonia (Pneumonitis) 10/2017 - 01/2017
2	Pulmonary Infarction 01/2016 - 11/2010
2	Infarction (Infarctions) 05/2015 - 06/2009
2	Cryptococcal Meningitis 01/2014 - 06/2013
2	Hemorrhage 05/2013 - 05/2009
2	Abdominal Pain (Pain, Abdominal) 01/2012 - 04/2010
2	Pulmonary Aspergillosis 12/2010 - 06/2009
1	Kidney Diseases (Kidney Disease) 03/2021
1	Sepsis (Septicemia) 03/2021
1	Bacteremia 03/2021
1	Chronic Renal Insufficiency 03/2021
1	Coccidioidomycosis 01/2021
1	Diabetes Mellitus 01/2021
1	Sinusitis 01/2018
1	Hypertension (High Blood Pressure) 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Bacterial Pneumonia 10/2017
1	Community-Acquired Infections 10/2017
1	Mucositis 01/2017
1	Seroma 01/2017
1	Azotemia 01/2017
1	Schistosomiasis mansoni 01/2016
1	Breakthrough Infections 01/2016

Drug/Important Bio-Agent (IBA)

15	Pharmaceutical PreparationsIBA 09/2021 - 11/2006
13	isavuconazoleIBA 01/2021 - 08/2009
11	TriazolesIBA 01/2019 - 12/2008
10	Voriconazole (Vfend)FDA LinkGeneric 01/2019 - 06/2009
10	Antifungal AgentsIBA 01/2019 - 01/2007
8	Anti-Bacterial Agents (Antibiotics)IBA 09/2022 - 01/2008
8	Micafungin (FK463)FDA Link 10/2018 - 01/2008
7	galactomannanIBA 01/2017 - 07/2006
6	Biomarkers (Surrogate Marker)IBA 09/2021 - 11/2008
6	Fluconazole (Zonal)FDA LinkGeneric 01/2021 - 05/2011
6	Amphotericin B (Amphotericin)FDA LinkGeneric 10/2019 - 01/2007
6	deoxycholate drug combination amphotericin BIBA 10/2018 - 08/2005
6	liposomal amphotericin B FDA Link 01/2017 - 08/2010
6	EchinocandinsIBA 12/2015 - 04/2007
5	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 08/2004
4	ProdrugsIBA 12/2017 - 01/2016
4	Flucytosine (Ancobon)FDA Link 07/2013 - 08/2005
4	Anidulafungin FDA Link 10/2012 - 06/2009
3	Praziquantel (Biltricide)FDA Link 09/2021 - 01/2016
3	Itraconazole (Sporanox)FDA LinkGeneric 06/2017 - 08/2012
3	posaconazole FDA Link 02/2012 - 12/2010
2	Polypropylenes (Polypropylene)IBA 01/2021 - 01/2017
2	olorofimIBA 01/2018 - 11/2016
2	Caspofungin (Cancidas)FDA Link 10/2011 - 04/2007
2	polyglucosanIBA 11/2010 - 11/2008
1	Tazobactam Drug Combination Piperacillin (Zosyn)FDA LinkGeneric 03/2021
1	Piperacillin FDA LinkGeneric 03/2021
1	VaccinesIBA 01/2017
1	Amikacin (A.M.K)FDA LinkGeneric 01/2017
1	Fosfomycin FDA Link 01/2017

Therapy/Procedure

21	Therapeutics 01/2019 - 02/2007
7	Sutures (Suture) 09/2022 - 05/2009
7	Length of Stay 01/2022 - 01/2008
6	Herniorrhaphy 09/2019 - 01/2007
3	Laparotomy 11/2020 - 01/2017
2	Myofascial Release Therapy 01/2021 - 09/2020
2	Mass Drug Administration 01/2020 - 01/2016
2	Splenectomy 09/2019 - 01/2012
2	Catheters 01/2014 - 04/2011
2	Colectomy 05/2013 - 05/2009
2	Salvage Therapy 02/2012 - 04/2007
2	Drug Therapy (Chemotherapy) 05/2010 - 02/2007
2	Nephrectomy 10/2009 - 05/2009
2	Ablation Techniques 05/2009 - 01/2007
1	Operative Surgical Procedures 01/2022
1	Ambulatory Care (Outpatient Care) 01/2018
1	Mechanical Ventilators (Ventilator) 10/2017
1	Thoracotomy 09/2017
1	Laparoscopic Cholecystectomy 02/2016
1	Appendectomy 02/2016